International Journal of Computer and Communication Technology IJCCT
ISSN: 2231-0371
Abstracting and Indexing
IJCCT
Sequence Alignment and Phylogenetic Tree Construction of Malarial Parasites
Sk. Mujaffor
M.Tech (2nd Yr.), ITER, S´O´A University
Tripti Swarnkar
Deptt. Of CA, SOA University Bhubaneswar
Raktima Bandyopadhyay
Dept. of Bioinformatics, Vidyasagar University,
Abstract
Sequence alignment is one of the basic problems in computational biology that has helped researchers analyze biological sequences. The analysis has helped biologists to detect pathogens ;to develop drugs, and to predict the secondary and tertiary structure of a protein and identity common genes. The objective of the Phylogenetic tree is to determine the branch length and to figure out how the evolutionary tree has been generated . One way to tackle MSA is to use Hidden Markov Models (HMMs), which are known to be very powerful in the related problem domain of speech recognition. The fully trained model is applied to draw a valid conclusion about the evaluation of malarial parasites.
Recommended Citation
[1] A. L. Delcher, et al., "Alignment of whole genomes," Nucl. Acids Research, vol. 27, pp. 2369-2376, 1999. [2] D. Gusfield, Algorithms on Strings, Trees and Sequences:Computer cience and Computational Biology .Cambridge University Press, 1997. [3] M. Tompa, "Lecture notes on Biological Sequence Analysis," University of Washington, Seattle, Technical report, 2000. [4] Neil C. Jones and Pavel A. Pevzner, 2004 –“An Introduction toBioinformatics Algorithms”.[5] Richard Durbin,Eddy, Mitchison, 1998-“Biological Sequence Analysis”.